Description
LIF acts on its target cells via the activation of the LIF-receptor (LIFR) complex. The LIFR complex requires heterodimerisation of the two low affinity components LIFR and glycoprotein 130 (gp130), where combination transforms a low-affinity binding complex into a high- affinity binding site. Activation of the LIFR complex can trigger several signal transduction paIn LIF-induced heterodimerization with the LIFR, only the CBM of gp130 contacts LIF. The LIFR contributes mainly with its Ig-like domain to LIF binding